Hello,
I was quite frankly pulling my hair out. Then I I uninstalled v10.5.4 and installed an archived driver v10.4.10 r2558 from earlier in 2017 and everything seems to be working fine now.Just for information, I confirmed this problem on two separate PC's running Windows 10, one is 1709 Build 16299.248 and 1709 Build 16299.192 with exactly the same result. I read that some people have had issues with AVG antivirus but I am not using it. One PC is running ESET antivirus and the other is just running vanilla Windows Defender.
Please help.
I didn't find the right solution from the Internet.
References:-
http://www.3dconnexion.com/forum/viewtopic.php?f=25&t=35681
Thanks